5^th World Heart and Brain Conference September 24-26, 2018 Abu Dhabi, UAE

Aizhan Nurgaliyeva has worked as a Research Scientist, Assistant Professor of Medical Diseases and is currently pursuing her Master’s degree at Karaganda State Medical University. She is the author of several articles in Russian and foreign magazines. She was the Deputy Chairman of Postdoctoral Researchers Council of Karaganda State Medical University. Her interest is in impact of depression and anxiety on quality of life of persons with high cardiovascular risk.

Statement of the Problem: According to WHO, Cardiovascular Diseases (CVD) is the principal cause of death in the whole world. It is estimated that 17.5 million people died because of CVD in 2012, it was 31% of all cases of death in the world. The largest evidential base, confirming adverse impact of psychosocial characteristics on risk of development, course and prognosis of CVD, taking into account evidence class (IIA), evidence level (В) and evidence degree according to GRADE (strong), presented towards such factors as psychosocial stress at the work place and in the family, depression, anxiety, aggression, low social and economic status, social isolation, personality type D. Purpose of this research is study of depression impact on quality of life of persons with high cardiovascular risk. Method: 3,488 respondents were examined among population. Summary cardiovascular risk according to SCORE scale was determined in all respondents and depression state according to questionnaire PHQ-9. Quality of life was estimated by questionnaire SF-36. Result: Comparing functional correlation interrelations between quality of life indicators in two groups with high cardiovascular risk (less 1%) and high (more 1%), converse correlation relationships were detected between indicator ВP (pain) and МН (psychological health), which was r=-0.53 in the first group and r=-0.71 in the second group, which can indicate on weakening of psychological health in case of increased pain. Correlation relationship between indicator ВP (pain) and VT (viability), equal to r=-0.55 in the first group and r=-0.62 in the second group, can provide evidence of vital activity reduction in case of pain intensity increase. Conclusion: Depression in persons with high cardiovascular risk affects such indicators of quality of life as psychological health and viability. Evaluation of depression degree and its correction shall be included into program on prevention of cardiovascular diseases and their complications.

Botagoz Baidildina is currently a Master's Student Research Scientist. She is also an Assistant Professor of Therapeutic Disciplines, Karaganda State Medical University. She is the author of several publications in Russian and foreign journals. Her interest is in diagnostic and prognostic value of biomarkers in the development of cardiovascular disease.

Statement of the Problem: Cardiovascular Diseases (CVD) is primary cause of mortality and morbidity in the whole world. Early detection of cardiovascular diseases and detection of patients with high level of development of adverse effects will allow timely prevention of serious consequences or death. Consequently, search of sensitive biomarkers is crucial task. The aim is to study level of troponin, N-terminal pro-brain natriuretic peptide (NT-ProBNP), СK-MB and Fatty Acid-Binding Protein, cardiac form (Н-FABP) depending on common risk factors of cardiovascular events. Method: Screening was performed among population of Karagandinskaya oblast. Sampling is composed of 1,240 people (852 women, 352 men) at the age from 18 to 65 years old (average age is 53.2±9.4 years). Level of markers was studied in groups depending on degree of cardiovascular risk according to scale Score with low (less 1%), medium (1-5%), high (5%-10%) and very high (10% and more). Result: Results testify that significant differences in Н-FABP level were detected in respondents with different level of cardiovascular risk, depending on level of cardiovascular risk (Z=45, 44; р=0.0001), the lowest level is in group with low risk (1756 pg/ml), the highest level is in group with high and very high risk (2443 pg/ml). It was established during analysis of markers level depending on risk factors, that Н-FABP level was different depending on age (р=0.0001), on body mass index and waist measurement (р=0.001), on level of blood pressure (р=0.0001), presence of hypercholesterolemia (р=0.001), in persons with heart attack (р=0.013). NT-ProBNP level was significantly higher among people with heart attack (р=0.006), with abdominal obesity (р=0.015), increased systolic blood pressure (р=0.022). Conclusion: Combination of high cardiovascular risk with increase of titer Н-FABP is indicative of diagnostic and prognostic value of this marker among population.

Statement of the Problem: The Coronary Artery Disease (CAD) is the cause of Sudden Cardiac Death (SCD) in 80% of cases. In SCD structure, 75% of deaths are due to Ventricular Tachyarrhythmia (VTA). The main method of SCD prevention is Implantable Cardioverter-Defibrillator (ICD). However, about 25% of patients didn’t receive an ICD shock therapy; most of these patients are from the primary prevention group. So it is necessary to find out new predictors of VTA. Aim of the study is the possibility of Cardiac Scintigraphy (CS) with ¹²³I-metaiodo-benzylguanidine (123I-MIBG) in VTA incidence assessment in patients with CAD and reduced Left Ventricle Ejection Fraction (LVEF). Method: Patients (male: 19, age: 63.2±7.7 years) with CAD and primary SCD prevention indications were examined. All patients before ICD implantation underwent echocardiography and CS with 123I-MIBG. LVEF was 31.66±3.88%. Planar and SPECT images were acquired after intravenous administration of 123I-MIBG. Early and delayed heart/mediastinum ratio (H/M), 123I-MIBG Washout Rate (WR), Summed Score on early (SSe) and delayed (SSd) scintigrams were calculated. Patients were divided into two groups according to the VTA incidences during sixth month follows-up. The first group consisted of patients with VTA events, second group without VTA. Results of scintigraphy and LVEF before ICD implantation were compared. Findings: The first group consisted of 18 (85.7%) patients (male: 17, age: 62.5±7.9 years) with VTA events. The second group consisted of 3 (14.3%) patients (male: 2, age: 67.6±5.0 years) without VTA events. There were significant differences in SSe-29.55±14.97% in the first group and 11.33±6.35% in the second group (р=0,006). As well as SSd were statistically different in groups 36.77±1.72% and 18.66±4.04% (р=0.03), respectively. Other indicators did not show significant differences. Conclusion & Significance: These preliminary results showed that index of regional innervation (SS), assessed by cardiac 123I-MIBG imaging is more perspective predictors of VTA events then H/M, WR and LVEF.